Traditionally, drugs are released in an immediate or extended fashion. However, in recent years, pulsatile drug release systems are gaining growing interest. A pulsatile drug release, where the drug is released rapidly after a well defined lag-time, could be advantageous for many drugs or therapies. Pulsatile drug delivery systems (PDDS) are gaining importance as these systems deliver the drug at specific time as per the pathophysiological need of the disease, resulting in improved patient therapeutic efficacy and compliance. This system is designed for chronopharmacotherapy, which is based on circadian rhythm. The principle basis for the use of pulsatile release is for the drugs where a constant drug release, i.e., a zero-order release is not preferred. Ideally, with a pulsatile system, the drug is released rapidly and transient after a defined lag time of no drug release. Diseases wherein PDDS are promising include asthma, peptic ulcer cardiovascular diseases, arthritis attention deficit syndrome in children. Marketed product like Pulsicap®, Ritalin® and Pulsys® are based on pulsatile release system.
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